e-oligos Oligo Modifications: End Modifiers
All modifications can be broadly termed as end modifiers as these modify the 5’ or 3’ end. This section contains a list of modifications that are used to modify the ends for conjugation to other modifications or to solid surfaces including magnetic beads. The end modifiers add a reactive functional group which can be used for conjugation. The common functional groups that can be added are amino, carboxyl and thiol. All of these can be combined with different length of spacers (C3, C12, Spacer 9 and 18) to add physical distance of the functional group from the end of the oligonucleotide sequence.