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Oligo Modifications List | Oligo Modifications Reference Category
Modification : 2-Amino Purine
Reference Catalog Number 26-6505
Category Others
Modification Code 2-APd
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 313.21
Extinction Coeficient (ec) 15.4
Technical Info (pdf) PS26-6505.pdf
Catalog NoScalePrice
26-6505-0550 nmol$175.50
26-6505-02200 nmol$175.50
26-6505-011 umol$228.15
26-6505-032 umol$342.22
26-6505-1010 umol$1,825.20
26-6505-1515 umol$2,281.50

Discounts are available for 2-Amino Purine!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Thio-2-dT (S2dT)
Convertible dG (2-F-dI)
2-Amino dA
2-Amino Purine ribose

2-Amino Purine (2-AP) is a fluorescent molecule that is classified as an adenine and guanine analog, and thus can pair with both thymine and cytosine bases (1). It is an attractive choice for use as a probe in nucleic acid secondary structural studies, both because its fluorescence is highly sensitive to the nature of the local environment, and because it usually does not significantly affect duplex stability (2). Examples include the hairpin-loop structure of the (CAG)8 repeat, involved in several neurodegenerative disorders—2AP substituted for A (3), the G-quadruplex telomeric structure [AGGG(TTAGGG)3]—2AP substitute for A (4). 2-AP also has been used to characterize the effects of DNA mismatch repair on mutagenesis induced by several different nucleoside analogs (5).

References
1. Negishi, K.; Bessho, T.; Hayatsu, H. Nucleoside and nucleobase analog mutagens. Mutat. Res. (1994), 318: 227-238.
2. Ballin, J.D., et al. Local RNA Conformational Dynamics Revealed by 2-Aminopurine Solvent Accessibility. Biochemistry (2008), 47: 7043-7052.
3. Degtyareva, N.N.; Reddish, M.J.; Sengupta, B.; Petty, J.T. Structural Studies of a Trinucleotide Repeat Sequence Using 2-Aminopurine. Biochemistry (2009), 48: 2340-2346.
4. Kimura, T.; Kawai, K.; Fujitsuka, M.; Tetsuro, M. Monitoring G-quadruplex structures and G-quadruplex-ligand complex using 2-aminopurine modified oligonucleotides. Tetrahedron (2007), 63: 3585-3590.
5. Negishi, K.; et al. Binding specificities of the mismatch binding protein, MutS, to oligonucleotides containing modified bases. Nucleic Acids Res. Supplement No. 1 (2001), 221-222.
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