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Oligo Modifications List | Oligo Modifications Reference Category
Modification : dihydro dU (5-6 DHdU)
Reference Catalog Number 26-6683
Category Minor Bases
Modification Code 5-6 DH dU
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 292.19
Extinction Coeficient (ec) 8.4
Technical Info (pdf) PS26-6683.pdf
Catalog NoScalePrice
26-6683-0550 nmol$234.00
26-6683-02200 nmol$234.00
26-6683-011 umol$304.20
26-6683-032 umol$456.30
26-6683-1010 umol$2,433.60
26-6683-1515 umol$3,042.00

Discounts are available for dihydro dU (5-6 DHdU)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Dihydro dU (5,6-DHU) is primarily used in studies of irradiative DNA damage and associated repair mechanisms. In the cell, 5,6-DHU DNA lesions are formed by gamma irradiation of deoxycytosine under anoxic conditions, resulting in deamination followed by addition of hydrogen at C5 and C6 of the base. DHU is highly mutagenic, leading to C-to-T transitions at the mutation site (because DNA polymerase inserts A opposite the 5,6-DHU lesion) (1). Because DHU is recognized and removed by endonuclease III and other eukaryotic endo III homologs, DHU-modified oligos are used in model systems for studying DNA damage and repair mechanisms.

References
1. Liu, J., Doetsch, P.W. Escherichia coli RNA and DNA polymerase bypasss of dihydrouracil: mutagenic potential via transcription and replication. Nucleic Acids Res. (1998), 26: 1707-1712.
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