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Oligo Modifications List | Oligo Modifications Reference Category
Modification : Amino C7
Reference Catalog Number 26-6406
Category Conjugation Chemistry & End Modifiers
Modification Code AmC7
5 Prime N
3 Prime Y
Internal N
Molecular Weight (mw) 209.18
Technical Info (pdf) PS26-6406.pdf
Catalog NoScalePrice
26-6406-0550 nmol$45.00
26-6406-02200 nmol$45.00
26-6406-011 umol$58.50
26-6406-032 umol$87.75
26-6406-1010 umol$468.00
26-6406-1515 umol$585.00
Related Modifications
Amino dA C6
Amino C6
Amino Serinol
Amino dT C6
Amino dG C6
Amino C3
Amino C6 U
Amino dC C6
Amino C12

Amino Linker C7 can be used to incorporate an active primary amino group onto the 3’-end of an oligonucleotide followed by conjugation to the desired NHS activated ligand. The amino C7 thus becomes internal to the 3' end conjugated ligand. The amino group is separated from the 3’-end nucleotide base by a 7-carbon spacer arm to reduce steric interaction between the amino group and the oligo.
The presence of the primary amino group allows the user to label the oligo with a variety of different ligands for affinity, reporter or protein moieties (as NHS esters or isothiocyanates), depending on the application. Examples include biotin, digoxigenin, and fluorescent dyes or quenchers, magnetic beads and enzymes (for example, alkaline phosphatase).


The primary amine labelled oligos can also be conjugated to carboxyl functional groups usually for solid supports applications using EDC mediated reaction as shown in the figure below.


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