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Oligo Modifications List | Oligo Modifications Reference Category
Modification : Thymidine Glycol
Reference Catalog Number 26-6487
Category Minor Bases
Modification Code TG
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 338.21
Extinction Coeficient (ec) 8.7
Technical Info (pdf) PS26-6487.pdf
Catalog NoScalePrice
26-6487-0550 nmol$350.00
26-6487-02200 nmol$350.00
26-6487-011 umol$410.00
26-6487-032 umol$615.00
26-6487-1010 umol$3,280.00
26-6487-1515 umol$4,100.00

Discounts are available for Thymidine Glycol !
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Thymidine Glycol is classified as an oxidized nucleotide, and is primarily used in studies of oxidative DNA damage and associated repair mechanisms. In the cell, thymidine glycol DNA lesions are formed when the 5,6-double bond of thymidine is oxidized by oxidative metabolic processes, ionizing radiation, or industrial chemical oxidizers like potassium permanganate and osmium tetroxide. Although it does not appear to be mutagenic, it generates more structural distortion to the double helix than any other oxidatively-damaged base. Possibly as a result of this, thymidine glycol effectively blocks DNA polymerases, resulting in stalled replication forks, making it a potentially lethal lesion. However, despite the more extensive structural distortion, thymidine glycol lesions are most commonly repaired by the BER, rather than the NER mechanism (1,2).

References
1. Hatahet, Z., Wallace, S.S. Translesion DNA Synthesis. in DNA damage and repair. Volume I (1998), Humana Press: 231-232.
2. Nilsen, H., Krokan, H.E. Base excision repair in a network of defence and tolerance. Carcinogenesis (2001), 22: 987-998.
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