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Oligo Modifications List | Oligo Modifications Reference Category
Modification : dihydro dT (5-6 DHT)
Reference Catalog Number 26-6890
Category Minor Bases
Modification Code 5-6 DHT
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 306.21
Extinction Coeficient (ec) 8.7
Technical Info (pdf) PS26-6890.pdf
Catalog NoScalePrice
26-6890-0550 nmol$234.00
26-6890-02200 nmol$234.00
26-6890-011 umol$304.20
26-6890-032 umol$456.30
26-6890-1010 umol$2,433.60
26-6890-1515 umol$3,042.00

Discounts are available for dihydro dT (5-6 DHT)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
dihydro dU (5-6 DHdU)
dihydro dC (5-6 DHC)
dihydro rU (5-6 DH rU)

Dihydro dT (5,6-DHT) is primarily used in studies of irradiative DNA damage and associated repair mechanisms. In the cell, DHT DNA lesions are formed by gamma irradiation of deoxythymine under anoxic conditions, resulting in the addition of hydrogen at C5 and C6 of the thymine ring. DHT, unlike DHU (see its technical sheet), by itself appears to be neither mutagenic nor a replication block. However, when clustered with another lesion, e.g., 8-oxo-dG, there is evidence that the presence of DHT significantly enhances the mutagenicity of the other lesion (1). Because DHT is recognized and removed by endonuclease III and other eukaryotic endo III homologs, DHT-modified oligos are used in model systems for studying DNA damage and repair mechanisms.

1. Shikazono, N., Pearson, C., O’Neill, P., Thacker, J. The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA. Nucleic Acids Res. (2006), 34: 3722-3730.

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