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Oligo Modifications List | Oligo Modifications Reference Category
Modification : Convertible dA (O6-Phenyl-dI)
Reference Catalog Number 26-6921
Category Others
Modification Code O6-Phenyl-dI
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 830.92
Extinction Coeficient (ec) 15.4
Technical Info (pdf) PS26-6921.pdf
Catalog NoScalePrice
26-6921-0550 nmol$216.00
26-6921-02200 nmol$216.00
26-6921-01, 1 umol$296.00
26-6921-032 umol$315.90
26-6921-1010 umol$1,684.80
26-6921-1515 umol$2,527.20

Discounts are available for Convertible dA (O6-Phenyl-dI)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Convertible dU (O4 Triazolyl dU)
Convertible dG (2-F-dI)
Convertible dA (O6-Phenyl-dI)

O6-Phenyl-deoxyinosine (O6-Ph-dI) is classified as a convertible dA nucleotide. After incorporation into an oligo, reaction of the O6-phenyl on the inosine base with a primary amine displaces the oxygen atom, and converts the nucleotide into a N6-substituted dA. Oligos containing O6-Ph-dI modifications are useful precursors in studies requiring a base-modified dA in which the modification is a specific moiety. For example, O6-Ph-dI modified oligos have been reacted with 1,4-diaminobutane(1) in order to subsequently form a DNA molecule with active amines at the N6 position of several A positions in the oligo, for use as part of an affinity purification matrix. Oligos containing O6-Phenyl-dI modifications are also useful precursors in studies requiring cross-linking, at A position(s), between oligos, or between an oligo and an enzyme (2)

References
1. Larson, C.J.; Verdine, G.L. A High-Capacity Column for Affinity Purification of Sequence-Specific DNA Binding Proteins. Nucleic Acids Res. (1992), 30: 3525.
2. Corn, J.E.; Berger, J.M. FASTDXL. Structure (2007), 15: 773-780.
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