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Oligo Modifications List | Oligo Modifications Reference Category
Modification : TET-Azide
Reference Catalog Number 26-6724
Category Click Chemistry
Modification Code TET-N3
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 596.2
Technical Info (pdf) PS26-6724.pdf
Catalog NoScalePrice
26-6724-0550 nmol$450.00
26-6724-02200 nmol$450.00
26-6724-011 umol$877.50
26-6724-032 umol$877.50
26-6724-1010 umol$4,680.00
26-6724-1515 umol$5,850.00

TET (Tetrachloro fluorescein)-Azide is a fluorescent dye containing a terminal azide group. TET has an absorbance maximum of 522 nm and an emission maximum of 538 nm. The presence of the azide allows the user to use “Click Chemistry” (a [3+2] cycloaddition reaction between alkynes and azides, using copper (I) iodide as a catalyst) to conjugate the TET-Azide to a terminal alkyne-modified oligo with extremely high regioselectivity and efficiency (1,2). Preparation of the alkyne-modified oligo can be achieved using the 5’-Hexynyl modifier (see its respective tech sheet for details).

References
1. Huisgen, R. Angew. Chem. Int. Ed. (1963), 2: 565-568.
2. Rostovtsev, V.V., Green, L.G., Fokin, V.V., Sharpless, K.B. A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective Ligation of Azides and Terminal Alkynes. Angew. Chem. Int. Ed. (2002), 41: 2596-2599.
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