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Oligo Modifications List | Oligo Modifications Reference Category
Modification : 8-amino-dA
Reference Catalog Number 26-6535
Category Duplex Stability
Modification Code 8-am-dA
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 328.22
Extinction Coeficient (ec) 1
Technical Info (pdf) PS26-6535.pdf
Abvsorbance MAX 1
Emission MAX 1
Absorbance EC 15.4
Catalog NoScalePrice
26-6535-0550 nmol$355.00
26-6535-02200 nmol$355.00
26-6535-011 umol$461.50
26-6535-032 umol$692.25
26-6535-1010 umol$3,692.00
26-6535-1515 umol$4,615.00

Discounts are available for 8-amino-dA!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

8-Amino-deoxyAdenosine (8-Amino-dA) is an 8-amino-purine that is most commonly used to study the structural and functional properties of triple helices. The 8-amino group is able to form an additional Hoogsteen purine-pyrimidine hydrogen bond, which serves to increase triple helix stability (1). Moreover, it has been shown that triple-helix-forming oligos (TFO) containing 8-amino-dA form stable helices at neutral pH, instead of under acidic conditions (2). This property may be relevant for design of TFOs slated for in vivo work, which generally occurs under physiological pH (7.3-7.4) conditions.

References
1. Cubero, E., Avino, A., de la Torre, B.G., Frieden, M., Eritja, R., Luque, F.J., Gonzalez, C., Orozco, M. Hoogsteen-based parallel-stranded duplexes of DNA. The effect of 8-amino derivatives. J. Am. Chem. Soc. (2002), 124: 3133-3142.
2. Zhu, Q., Delaney, M.O., Greenberg, M.M. Observation and elimination of N-acetylation of oligonucleotides prepared using fast-protecting phosphoramidites and ultra-mild deprotection. Bioorg. Med. Chem. Lett. (2001), 11: 11105-1107.
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