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Oligo Modifications List | Oligo Modifications Reference Category
Modification : DBCO-TEG (5')
Reference Catalog Number 26-6928
Category Click Chemistry
Modification Code DBCO-TEG
5 Prime Y
3 Prime N
Internal N
Molecular Weight (mw) 570.57
Technical Info (pdf) PS26-6928.pdf
Catalog NoScalePrice
26-6928-0550 nmol$310.00
26-6928-02200 nmol$310.00
26-6928-011 umol$415.00
26-6928-032 umol$622.50
26-6928-1010 umol$3,320.00
26-6928-1515 umol$4,150.00

Discounts are available for DBCO-TEG (5')!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Azide-C4 NHS (butyrate)
DBCO-dT
DBCO-TEG (5')
DBCO-C6 NHS
Azide C3 3'
Azide C6 (5')
Azide dT (5')
Azide-C2 NHS
DBCO-C2 NHS
BCN-1 (bi cyclooctyne)
DBCO PEG4 NHS
DBCO PEG13 NHS
DBCO PC NHS

DBCO-TEG and DBCO-dT direct conjugation modifications have been discontinued due to instability and low overall performance. We suggest to use the alternates that are post synthesis conjugation using DBCO-NHS for amino conjugation or DBCO-Maleimide for thiol conjugation.

Click here for a list of post synthesis DBCO Modifications


Cyclooctyne-based modifications offers the ease of copper-free click reagents. These are simple to use and has excellenet click performance in 17 hours or less at room temperature. Gene Link offers 5'-DBCO-TEG for preparing oligos with 5’-DBCO and a 15 tom triethylene glycol spacer arm, DBCO-dT for inserting a DBCO group at any position within the oligonucleotide and DBCO-sulfo-NHS Ester is also offered for post-synthesis conjugation reactions. DBCO-modified oligos may be conjugated with azides in organic solvents, such as DMSO, or aqeous buffers. Depending on the azide used, the reaction will go to completion in 4-17 hours at room temperature.



Glen Report 27.1: Technical Brief - DBCO-dT - An Unusual Case of Iodine Sensitivity






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