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Oligo Modifications List | Oligo Modifications Reference Category
Modification : Thio-4 dU (s4dU)
Reference Catalog Number 26-6445
Category Others
Modification Code s4dU
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 306.23
Technical Info (pdf) PS26-6445.pdf
Catalog NoScalePrice
26-6445-0550 nmol$354.00
26-6445-02200 nmol$354.00
26-6445-011 umol$460.20
26-6445-032 umol$531.00
26-6445-1010 umol$3,681.60
26-6445-1515 umol$4,602.00

Discounts are available for Thio-4 dU (s4dU)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Thiol SS Dipod (DTPA)
Thiol C6 dT
Thio-4-dT (S4dT)
Thiol SS Dipod (DTSPA)
Thio-4-rU (s4U)
Thio-2-dT (S2dT)
Thio 6-dG (s6dG)
Thiol SS-C3
Thio-4 dU (s4dU)
Thiol SS-C6
6-Thio-dG, 4-Thio-dT and 4-thio-dU are very useful modifications for photo cross-linking and photoaffinity labelling experiments. Oligos containing 2-thio-dT are useful in examining protein-DNA interaction by acting as photosensitizing probes. The thiocarbonyl group in 2-thio-dT is especially interesting in that it is available to react with compounds associating with the minor groove of DNA. 2-Amino-A forms a very stable base pair with T containing three hydrogen bonds but the stability of the base pair with 2-thio-T is greatly diminished. Due to steric interactions between the 2-thio group of thymidine and the 2-amino group of 2-amino-A, the base pair contains only a single hydrogen bond. Oligos containing 2-amino-dA and 2-thio-dT exhibit high affinity for natural oligonucleotides but show little affinity for other similar oligos even of a complementary sequence.

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