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Oligo Modifications List | Oligo Modifications Reference Category
Modification : d5SICS
Reference Catalog Number 26-6562
Category Duplex Stability
Modification Code d5SICS
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 353.11
Extinction Coeficient (ec) 11
Technical Info (pdf) PS26-6562.pdf
Catalog NoScalePrice
26-6562-0550 nmol$1,285.20
26-6562-02200 nmol$1,285.20
26-6562-011 umol$1,670.76
26-6562-032 umol$2,506.14
26-6562-1010 umol$13,366.08
26-6562-1515 umol$16,707.60

Discounts are available for d5SICS!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
dDss
dNaM
dDs
dPa (pyrrole-2-carbaldehyde)

Base pair that achieves pair recognition through hydrophobic interactions.


The dNaM and d5SICS matched pair appears to be a very interesting novel base pair. These unnatural C-nucleosides have pair recognition that rivals the A-T and G-C pairing in the natural genetic alphabet. In addition, they have been shown to be well-replicated by DNA polymerases under steady-state conditions, regardless of sequence. The fidelity and efficiency of dNaM and d5SICS replication approach those of natural synthesis. Both dNaM and d5SICS are also efficiently transcribed by T7 RNA polymerase in either direction.

References


1. Seo, Y.J.; Matsuda, S.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131(14), 5046-7.
2. Seo, Y.J.; Hwang, G.T.; Ordoukhanian, P.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131(9), 3246-52.
3. Seo, Y.J.; Romesberg, F.E. ChemBioChem, 2009, 10(14), 2394-2400.
4. Hwang, G.T.; Hari, Y.; Romesberg, F.E. Nucleic Acids Res., 2009, 37(14), 4757-63.
5. Hari, Y.; Hwang, G.T.; Leconte, A.M.; Joubert, N.; Hocek, M.; Romesberg, F.E. ChemBioChem, 2008, 9(17), 2796-9.
6. Hwang, G.T.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130(44), 14872-82.
7. Leconte, A.M.; Hwang, G.T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130 (7), 2336-43.

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