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Oligo Modifications List | Oligo Modifications Reference Category
Modification : 8-Br rG
Reference Catalog Number 27-6446
Category RNA Oligo Synthesis
Modification Code 8-Br rG
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 424.11
Extinction Coeficient (ec) 11.5
Technical Info (pdf) PS27-6446.pdf
Catalog NoScalePrice
27-6446-0550 nmol$41.60
27-6446-02200 nmol$41.60
27-6446-011 umol$54.08
27-6446-032 umol$81.12
27-6446-1010 umol$432.64
27-6446-1515 umol$540.80

Discounts are available for 8-Br rG !
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
8-Br rG
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function(1). It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects (2,3).

References


1. R. Yajima, D. J. Proctor, R. Kierzek, et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chemistry & Biology 14, 23-30 (2007).
2. M. G. Goodman and W. O. Weigle. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proceedings of the National Academy of Sciences of the United States of America 81, 862-866 (1984).
3. S. Giorgio and S. C. Barao. Intracellular Leishmania amazonensis killing induced by the guanine nucleoside 8-bromoguanosine. Rev.Inst.Med.Trop.S.Paulo. 40(4), 1-9 (1998).

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