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Oligo Modifications List | Oligo Modifications Reference Category
Modification : Amino C6 Universal
Reference Catalog Number 26-6560
Category Others
Modification Code AmC6Uni
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 240.21
Technical Info (pdf) PS26-6560.pdf
Catalog NoScalePrice
26-6560-0550 nmol$510.00
26-6560-02200 nmol$510.00
26-6560-011 umol$545.00
26-6560-032 umol$585.00
26-6560-1010 umol$880.00
26-6560-1515 umol$1,350.00

Discounts are available for Amino C6 Universal!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Amino dA C6
Amino C6
Amino Serinol
Amino dT C6
Amino dG C6
Amino C3
Amino C6 U
Amino C6 Universal
Amino dC C6
Amino C12
Amino C7

Amino C6 universal is primarily offered for internal labeling for eventual conjugation to solid surface or other ligands. The internally placed Amino C6 will enable the oligo to fold. For 3' and 5' amino modification consider our other appropriate 3' and 5' amino modifications.

Amino C6 universal can be used to incorporate an active primary amino group at any position of an oligo. If inserted internally it will occupy a space of ~6 carbon atoms. This is helpful when the purpose is to have the oligo conjugated to a surface or ligand at this position and have the oligo fold. The amino group is used for conjugation. This can then be conjugated to a NHS Activated ligand. The amino group then becomes internal to the 5' end ligand. The amino group is separated from the 5’-end nucleotide base by a 6-carbon spacer arm to reduce steric interaction between the amino group and the oligo.
The presence of the primary amino group allows the user to label the oligo with a variety of different ligands for affinity, reporter or protein moieties (as NHS esters or isothiocyanates), depending on the application. Examples include biotin, digoxigenin, and fluorescent dyes or quenchers, magnetic beads and enzymes (for example, alkaline phosphatase).


The primary amine labelled oligos can also be conjugated to carboxyl functional groups usually for solid supports applications using EDC mediated reaction as shown in the figure below.


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