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Oligo Modifications List | Oligo Modifications Reference Category
Modification : DBCO-C2 NHS
Reference Catalog Number 26-6742
Category Click Chemistry
Modification Code DBCO-C2 N
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 288
Technical Info (pdf) PS26-6742.pdf
Catalog NoScalePrice
26-6742-0550 nmol$285.00
26-6742-02200 nmol$285.00
26-6742-011 umol$365.00
26-6742-032 umol$475.00
26-6742-1010 umol$1,248.00
26-6742-1515 umol$1,560.00
Related Modifications
Tetrazine methyl PEG4
Azide C3 3'
Alkyne- Serinol
Azide-C4 NHS (butyrate)
Azide-C2 NHS
Azide dT (5')
Azide C6 (5')
Alkyne-C2 NHS
BCN-1 (bi cyclooctyne)

This modification is a post synthesis NHS conjugation to a primary amino group thus an additional modification with an amino group is required. A C6 or C12 amino group can be placed at the 5' or for the 3' end a C3 or C7 amino and for internal positions an amino modified base is used, e.g Amino dT C6.

Click here for a complete list of Click Chemistry Oligo Modifications

Cyclooctyne-based modifications offers the ease of copper-free click reagents. These are simple to use and has excellenet click performance in 17 hours or less at room temperature. Gene Link offers 5'-DBCO-TEG for preparing oligos with 5’-DBCO and a 15 tom triethylene glycol spacer arm, DBCO-dT for inserting a DBCO group at any position within the oligonucleotide and DBCO-sulfo-NHS Ester is also offered for post-synthesis conjugation reactions. DBCO-modified oligos may be conjugated with azides in organic solvents, such as DMSO, or aqeous buffers. Depending on the azide used, the reaction will go to completion in 4-17 hours at room temperature.


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