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Oligo Modifications List | Oligo Modifications Reference Category
Modification : L-DNA Bases
Reference Catalog Number 26-6940
Category Others
Modification Code L-dN
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 330.23
Extinction Coeficient (ec) 10.67
Technical Info (pdf) PS26-6940.pdf
Catalog NoScalePrice
26-6940-0550 nmol$110.00
26-6940-02200 nmol$110.00
26-6940-011 umol$165.00
26-6940-032 umol$210.00
26-6940-1010 umol$1,492.00
26-6940-1515 umol$2,066.00

Discounts are available for L-DNA Bases!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
Magnetic Bead Oligo Conjugation
Locked Analog Bases (LNA-N)
Locked Analog G
Locked Analog T
L-RNA Bases
Locked Analog A
Locked Analog mC
L-DNA is the left-turning and mirror image version of natural DNA, as opposed to the naturally occurring right-turning version called D-DNA. L-DNA is more stable than D-DNA to enzymatic degradation by certain nucleases (1). Since the two enantiomers are identical in structure other than their chiral differences, their intrinsic physical properties are generally equal to each other. This includes duplex stability, solubility, and selectivity as D-DNA but form a left-helical double-helix. Because of its chiral difference, L-DNA does not bind to its naturally occurring D-DNA counterpart.

One important aspect of L-DNA is that it is poor at hybridizing to D-DNA (2). This confers multiple uses, one being that the incorporation of L-DNA into the stem of a molecular beacon as it allows stem invasion to be avoided (3). Other areas that it can play an important role in would be zip-code microarrays (2) and as molecular tags for PCR (4). When used in nanocarriers, L-DNA has greater cellular uptake as well as greater serum stability. It is good for also reducing interaction between aptamers and nanocarrier skeletons (5).

Gene Link synthesizes L-DNA oligos with any combination of D-DNA bases including fluorescent dyes and all other available modifications.


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