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Oligo Modifications List | Oligo Modifications Reference Category
Modification : IRDye QC-1N
Reference Catalog Number 26-6674
Category Quenchers
Modification Code IRDyeQC-1
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 1145.67
Technical Info (pdf) PS26-6674.pdf
Abvsorbance MAX 750
Catalog NoScalePrice
26-6674-0550 nmol$267.00
26-6674-02200 nmol$397.00
26-6674-011 umol$991.00
26-6674-032 umol$1,750.00
Related Modifications
IRDye700
IRDye800

IRDye QC-1 quencher is a post synthesis conjugation to a primary amino group thus an additional modification with an amino group is required. A C6 or C12 amino group can be placed at the 5' or for the 3' end a C3 or C7 amino and for internal positions an amino modified base is used, e.g Amino dT C6.

YIELD
NHS based modifications are post synthesis conjugation performed using a primary amino group. The yield is lower as compared to direct automated coupling of modifications that are available as amidites. Approximate yield for various scales are given below.

~2 nmol final yield for 50 nmol scale synthesis.
~5 nmol final yield for 200 nmol scale synthesis.
~16 nmol final yield for 1 umol scale synthesis


IRDye QC-1 is a non-fluorescent (dark) quencher compatible with a wide range of visible and near-infrared fluorophores (~500-800 nm). It has a wide available quenching range with the maxima in the range of 700-800 nm. IRDye QC-1 quenches common fluorophores with >97% efficiency. It is ideal for all IR dyes.

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