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Oligo Modifications List | Oligo Modifications Reference Category
Modification : N1-methyl pseudoUridine (m1-psi rU)
Reference Catalog Number 27-6532
Category Structural Studies
Modification Code m1-psi-rU
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 320.19
Extinction Coeficient (ec) 9.9
Technical Info (pdf) PS27-6532.pdf
Abvsorbance MAX 260
Catalog NoScalePrice
27-6532-0550 nmol$496.00
27-6532-02200 nmol$496.00
27-6532-011 umol$595.00
27-6532-032 umol$766.00

Discounts are available for N1-methyl pseudoUridine (m1-psi rU)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
pseudoiso dC (pidC)
pseudoUridine (psi rU)
RNA methylation occurs in a large selection of RNA nucleosides and this post transcriptional modification of RNA, carried out by a variety of RNA methyltransferases, appears in a wide variety of RNA species - including tRNA, mRNA, miRNA and RNA viruses. Over 90 methylated nucleosides have been found in tRNA and these play many significant roles in tRNA structure. In addition, methylation appears to mark the tRNA as mature, preventing its degradation as well as directing localization within the cell. mRNA, modified with 1-methylpseudouridine (1-Me-Ψ ) alone or in combination with 5-methylcytidine (5-Me-C), significantly increases protein expression in cells and mouse models. 1-Me-Ψ is also a modified nucleobase that can greatly enhance the properties of mRNA by reducing immunogenicity and increasing stability.

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