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Oligo Modifications List | Oligo Modifications Reference Category
Modification : propyne dU
Reference Catalog Number 26-6502
Category Antisense
Modification Code pdU
5 Prime Y
3 Prime Y
Internal Y
Molecular Weight (mw) 328.22
Extinction Coeficient (ec) 8.4
Technical Info (pdf) PS26-6502.pdf
Catalog NoScalePrice
26-6502-0550 nmol$97.50
26-6502-02200 nmol$97.50
26-6502-011 umol$126.75
26-6502-032 umol$190.12
26-6502-1010 umol$1,014.00
26-6502-1515 umol$1,267.50

Discounts are available for propyne dU!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Related Modifications
5-ca dC
N4-Ethyl dC
2'-O methyl G
2'-O methyl U
N6-Methyl dA (m6dA)
2'-O methyl A
Thio-2-dT (S2dT)
5-Me dC
2'-O methyl C
2'-O methyl Inosine
2-Amino dA
propyne dC
It has been shown that C-5 propyne analogs of dC and dT when substituted in phosphorothioate oligonucleotide imparts greater inhibition of gene expression due to increased binding affinity to the target mRNA and increased stability. Based on the above information antisense oligonucleotide could either be Phosphorothioated at all diester linkages or combined with substitutions of dC and dT by C-5 propyne analogs pdC and pdU. The use of propyne analogs is covered by patents and licensing agreements. The sale of propyne-modified oligos is for research use only. See license agreement*

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