Amino dA C6 can be used to internally incorporate an active primary amino group into either a DNA oligonucleotide or a chimeric oligo. The presence of the amino group allows the user to label the oligo with a variety of different affinity, reporter or protein moieties (as NHS esters or isothiocyanates), depending on the application. Examples include biotin, digoxigenin, and fluorescent dyes or quenchers, and enzymes (for example, alkaline phosphatase).